Fetal alcohol spectrum disorder is an overarching term that describes the extent of effects of prenatal alcohol exposure. It includes the range of neurodevelopmental findings and other medical findings specific for FAS. Measurability of characteristics depends on several factors, such as diagnostic instruments, multidisciplinary focus, etc. The objective of the contribution is to provide the primary early care givers with recommendations for FASD screening. It involves suggestions that deal with recognition, protection and intervention of children with FASD in the most elaborate and unbiased manner. Results of the study offer selective intention of screening in preschool-aged children. The research was conducted with 173 children aged from 3 to 7 years. The authors used their own concept of selected domains indicating the occurrence of impairments in FASD domains. Specific quantitative and qualitative research methods were assigned to them. The impairments relate to anthropometric deviations determining early occurrence of FASD. The authors have selected the domain of basic anthropometry: head circumference, height and weight and philtrum and the obtained results from domains: auditory processing, selected cognitive components, motor system, speech and sensory processing. Conclusions define basic criteria for FASD screening in general population and basic algorithm of distribution of recognized child in a system of early care in the SR. They rely on the fact that there is urgent demand in Slovakia to involve participants in active FASD care.