The article explores the relationship between the attitudes of the respondents towards transplantation and their sense of coherence. The presented results were obtained through the statistical analysis of data collected in a group of 467 students. The study used a self-designed questionnaire and scale to study attitudes of academic youth towards transplantation alongside Antonovsky’s Orientation to Life Questionnaire (SOC-29). The results obtained prove that there is no correlation that would justify the conclusion that the sense of coherence of the respondents has a statistically significant connection with their attitude towards transplantation. However, the sense of coherence positively correlates with one of the components of the attitude towards transplantation. This concerns the level of Knowledge, which means that people with a high sense of coherence are significantly more likely to have a higher level of Knowledge related to transplantation. The data confirmed the existence of a correlation between the level of knowledge of the respondents related to the issue of transplantation and all the components constituting a sense of coherence, i.e. a manageability, meaningfulness and comprehensibility. Conclusions formulated on the basis of the obtained results point to the necessity of taking up a contemporary pedagogical challenge, which is health education aimed at shaping social attitudes towards transplantation. An additional recommendation is to enrich educational programs with activities the goal of which is to create a high sense of coherence in their recipients, which, by definition, should have pro-health consequences for a wide group of beneficiaries.