The election of Joseph Biden for the office of the President of the United States has brought expectations of fundamental change in American foreign policy, including policy toward the Asia-Pacific/Indo-Pacific region. As observed in the last few months, the reality has been more complex as definite changes in the US Indo-Pacific policy are not as visible as expected. It is especially in respect of the US policy toward China being more a continuation than a change from Donald Trump’s approach. Changes are rhetorical rather than actual policies. The situation is different in the case of alliances, as Joe Biden offers much more commitment to allies like Japan or South Korea. Also, multilateral dimensions (both regional and global) witness some – however still limited – change. The main goal is to make a comparative analysis of Joe Biden’s policy toward Asia, referring to the administrations of Barack Obama and Donald Trump. Hence the strategies of pivot/re-balance toward the Asia of Obama, and the free and open Indo-Pacific strategy of Trump, will be examined. The analysis refers to the complex interdependence theory and the power transition theory. Methodologically, it is based on document analysis with comparative analysis.