Burnout has been widely reviewed and studied. However, the relationship between teacher burnout syndrome and curricular reform is rarely studied. Thus, the aim here is to report on the burnout syndrome among teachers during the implementation of the curriculum in Malaysia namely Integrated Secondary School Curriculum (ISSC). Two hundred and sixty four secondary school teachers who were involved in the ISSC program completed the Maslach Burnout Inventory (MBI) and the Secondary School Curricular Change Questionnaire (SSCCQ). The stepwise regression results showed that the emotional exhaustion (EE) predictor is overall workload and time sufficiency, depersonalization (DP) predictor is complexity of the ISSC, and personal accomplishment (PA) predictor is ISSC practicality. Preventing this phenomenon in the school system can lead to better retention rates among teachers.