This article is devoted to the problems that prevail in times from antiquity to the present day. The specter of an epidemic, known to humankind since the dawn of time, was a negative phenomenon, destabilizing contemporary life and having a significant impact on biological, social, economic and cultural aspects. It was impossible to protect against the epidemic – until the 19th century, medicine did much more damage than we might imagine. Doctors were powerless against diseases, they healed as much as they could, unable to overcome the specter of the coming plague. Is not that also the case today? COVID-19 is not much different from the “epidemics” that hit our country in previous centuries. Both in the past and today, there is no cure for the disease that prevails today, only to treat its external symptoms. The juxtaposition of some of the largest in the history of the world right now, and comparing them to the COVID-19 raging since autumn 2019 shows us that with the medicine of that time, we are not threatened with such depopulation of the world as it used to be... to our heritage, look at the works on the plagues to learn from them for the future. The article cites historical and literary sources, as well as older or newer studies, showing how much evil epidemics once caused, how people tried to protect against them, and if the threat appeared in their area, how it was fought.