The article presents a legal framework for entrepreneurs in the context of the programs of the European Space Agency (ESA). ESA has its own procurement and delivery system in which contractors can be entrepreneurs, including micro, small and medium sized ones (SMEs). Within the ESA system, entrepreneurs may be contractors themselves or be partners in consortia or be subcontractors of entrepreneurs (or consortia) that have concluded an order or supply contract for ESA. This article briefly presents ESA’s procurement procedure along with three selected clauses in ESA’s contracts: the provision of intellectual property rights, the “Best Practices” clauses for subcontractors and the special clauses ensuring participation of SMEs in ESA’s programs.