This paper examines the innovation and employability of National Youth Service Corps (NYSC) members for sustainable development in south-east Nigeria. The research design employed for this study was a descriptive survey. The population for this study comprises all NYSC members serving in southeast Nigeria. A purposive sampling technique was used to sample all 2019 Batch “C” who participated in the Post Mobilisation Workshop held on 27t - 29t January 2020. Also, a simple random sampling technique was used to select 400 NYSC members from each state of south-east Nigeria. In all, 2000 NYSC members participated in this study. The questionnaire that was used to collect data in this study was titled “Influence of Innovation on Employability of NYSC Members for Sustainable Development Questionnaire”. Percentages were used in describing the demographic characteristics of the respondents, and mean ratings were used to answer the research questions. The findings revealed that influence of innovation on employability of NYSC members for sustainable development in south-east Nigeria was positive. The main new innovation to enhance employability of NYSC members for sustainable development in south-east Nigeria was agro-allied. The main employability skills of NYSC members for sustainable development in south-east Nigeria were confidence skills. It was concluded that innovation positively influences employability of NYSC members. It was recommended that the NYSC commission should embark on introducing more innovative skills to NYSC members for them to be able to stand on their own after the NYSC programme.