The subject of the article is trade cooperation between Great Britain and Kenya in the context of the United Kingdom’s withdrawal from the European Union. The article characterizes the commercial cooperation of Great Britain and Kenya and discusses the trends existing in this field in recent years. The main threats to this cooperation that Brexit brings are presented, as well as the actions that states must implement to counteract the negative consequences of Brexit and the opportunities that Brexit potentially gives to deepening trade cooperation between countries. In addition, the political climate change that has occurred between countries in recent years, which has a significant impact on the implementation of economic cooperation, including trade, has been outlined. The purpose of the article is to present and evaluate the challenges that the countries face in the context of Brexit, which they must overcome in order to maintain and deepen trade cooperation. The main research problem is whether Brexit will weaken or accelerate trade relations between Great Britain and Kenya? The main hypothesis of the article is that Brexit causes great uncertainty about the future of trade cooperation between Great Britain and Kenya. However, it gives the opportunity to dynamize this cooperation, and Kenya can become a model partner for the United Kingdom within the concept of „Global Britain” promoted by London. Kenya’s positive development trends make it an increasingly attractive trading partner for Great Britain. However, Kenya wants to take advantage of the UK’s search for trading partners outside the European Union.