The article is an attempt to characterize the methodology of multidisciplinary empirical research, designed and implemented within technical, exact, natural, social, and humanistic sciences. Three paradigms have been characterized: Education 4.0, Industry 4.0, and Society 5.0. The author’s attention was drawn to the need for a clear formulation of detailed concepts as well as their content and context. The types of possible empirical research and the methods and techniques used in them were presented, attention was also drawn to the importance of the model used in the research. It was considered necessary to disseminate methodological knowledge for the reliable execution of empirical research, allowing for its repeatability, verification, and evaluation.