The international and domestic efforts directed toward establishing effective regulations of multinational enterprises (MNEs) activity in the human rights and environmental realms are currently entering an intriguing phase. The trend toward setting forth legally binding obligations applicable across their complex, transnational structures is gaining momentum, and the upcoming EU Corporate Sustainability Due Diligence Directive (CSDDD) may significantly contribute to this process. The research aim of this study is to examine how the draft CSDDD is woven into the present regulatory landscape, and what impact it may potentially have. Due to multicentricity of the legal sources’ systems in the member states, the EU law underway will also affect their constitutional orders. To tackle the research task, it is crucial to delineate the broader context of the challenges surrounding the enforcement of social and environmental accountability throughout global value chains, which arise at the intersection of the existing governance mechanisms’ quality, and the legal as well as organisational MNEs’ logics. These interconnected issues are addressed in the first section of the paper. The second section covers CSDDD as reflecting and potentially accelerating regulatory trends.